Brilliant breakdown of the proofreading bottleneck, which has always been the unsung hero problem in connectomics. The shift from pure labor intensity to algorithmic approaches like PATHFIDNER is kinda wild when u think about it. I remeber working adjacent to neuroscience projects and seeing how much human time went into trace validation. The 80x reduction could genuinly accellerate mouse brain timelines by years, not just margins.
Not a dumb question. One of many big unkowns. Right now basically no computational brain models simulate glia cells. And the data we have is even more scarce than the data on neurons. I wouldn't be surprised if future brain models also will incorporate glial data to account for their modulation.
... if one is able to emulate a human brain in sufficient faithfulness to be experimentally useful, does that not also imply one has created an emergent human mind that is due the same ethical protections as a biological human?
I very much share your intuition here - that at a certain degree of sophistication brain emulation research needs to deal with exactly these sorts of questions. Encouraging that there is already an existing field of neuro ethics that starts to take this line of thinking seriously.
Brilliant breakdown of the proofreading bottleneck, which has always been the unsung hero problem in connectomics. The shift from pure labor intensity to algorithmic approaches like PATHFIDNER is kinda wild when u think about it. I remeber working adjacent to neuroscience projects and seeing how much human time went into trace validation. The 80x reduction could genuinly accellerate mouse brain timelines by years, not just margins.
Forgive the dumb question, but do glial cells complicate things at all?
Not a dumb question. One of many big unkowns. Right now basically no computational brain models simulate glia cells. And the data we have is even more scarce than the data on neurons. I wouldn't be surprised if future brain models also will incorporate glial data to account for their modulation.
... if one is able to emulate a human brain in sufficient faithfulness to be experimentally useful, does that not also imply one has created an emergent human mind that is due the same ethical protections as a biological human?
I very much share your intuition here - that at a certain degree of sophistication brain emulation research needs to deal with exactly these sorts of questions. Encouraging that there is already an existing field of neuro ethics that starts to take this line of thinking seriously.