Toxic amino acids, peptides, and proteins — which first evolved as molecular weapons deployed by species in conflict — can also serve as blueprints for pharmaceutical innovation.
Great article! One quick note is that Casgevy doesn't work by fixing the mutated hemoglobin gene—it actually just knocks out a gene (BCL11A) that suppresses the production of fetal hemoglobin, leading to more production of the fetal hemoglobin gene that makes up for the mutated one.
Great article! One quick note is that Casgevy doesn't work by fixing the mutated hemoglobin gene—it actually just knocks out a gene (BCL11A) that suppresses the production of fetal hemoglobin, leading to more production of the fetal hemoglobin gene that makes up for the mutated one.
FASCINATING AND EDUCATIONAL--THANKS