sorry to be pedantic :') but your structure of pyroglutamic acid and TRF contains an error... the carbonyl is on the wrong carbon. it is supposed to be an amide, not an α-amino ketone.
My grandmother, who attended the Nobel Ceremony in 1977 when both Schally and Guillemin received the prize, recalled—when I shared your article with her—how Schally had asked her after the ceremony who received more applause, Guillemin or himself. She told him, ‘You did.’ She remembers he never appreciated having to share the prize, which really echoed the point of your article.
I'd buy one for a dollar, maybe a buck fifty -- no more than that. I've always thought these prizes do *far* more harm than good. In fact, there's no good at all that comes of them.
The caption for the photo of the 1977 Nobelists misidentifies the site of the ceremony. Only the Peace prize is awarded in Oslo; the others, including the Prize for Medicine or Physiology, are awarded by the King of Sweden in Stockholm. The photo brings back fond memories of attending the 1978 ceremony while I was on sabbatical at the Karolinska Institute.
Here you can see the interesting details of such an important collaboration. Dr Carlos Gual’s collaborations are printed on the official Nobel Lecture 1977.
I was delighted to read your article because it’s a close story to me. My late grandfather (died January 2024) is Dr Carlos Gual, close collaborator with Andrew Schally, Your article seems to overlook the importance of this collaboration and I am curious why. The first clinical studies on thyrotropin releasing hormone were carried out by Dr Gual.
The Nobel Prize is the worst thing that ever happened to science. It turns adult scientists into hysterical toddlers demanding the biggest piece of candy in the pile.
Darwin, Newton, and Aristotle didn't receive Nobel Prizes. So were they losers?
Thankfully, there is no Nobel Prize in mathematics, so mathematicians can respect each other for their genuine accomplishments, not for a stupid prize awarded by idiots.
I propose that the Nobel Prize be reformed as follows: Let it be awarded by an AI to other AIs. This way, human scientists can stop obsessing about the Prize and regain their dignity.
The two protagonists in your tale, with their millions of animal brains, sound more like Nazi concentration camp doctors than seekers after truth. I never heard of them before this and I wish them a well-deserved obscurity.
Mathematicians have an equivalent vice: the Fields Medal. In college, the math majors were the most elitist bunch I’d ever met, replete with a password-protected study room that was off-limits to non-math majors.
I was a math major in college and I went to grad school in math. I thought the mathematicians were a good bunch. It wasn't our fault that we were smarter than everyone else ;->.
I don't recall mathematicians caring much about the Fields Medal. Definitely not to the extent that some scientists are crazed about the NP.
Do you consider yourself a purist too? Never understood why mathematicians thought applying STEM to alleviate suffering was a less noble pursuit than STEM for STEM’s sake. The entire premise is dripping with ableist privilege.
sorry to be pedantic :') but your structure of pyroglutamic acid and TRF contains an error... the carbonyl is on the wrong carbon. it is supposed to be an amide, not an α-amino ketone.
You're right, I'm not sure how I missed this! I'll see if we can update this with the correct structure.
My grandmother, who attended the Nobel Ceremony in 1977 when both Schally and Guillemin received the prize, recalled—when I shared your article with her—how Schally had asked her after the ceremony who received more applause, Guillemin or himself. She told him, ‘You did.’ She remembers he never appreciated having to share the prize, which really echoed the point of your article.
I'd buy one for a dollar, maybe a buck fifty -- no more than that. I've always thought these prizes do *far* more harm than good. In fact, there's no good at all that comes of them.
The caption for the photo of the 1977 Nobelists misidentifies the site of the ceremony. Only the Peace prize is awarded in Oslo; the others, including the Prize for Medicine or Physiology, are awarded by the King of Sweden in Stockholm. The photo brings back fond memories of attending the 1978 ceremony while I was on sabbatical at the Karolinska Institute.
Thanks, Leon, for this helpful comment. We'll update the caption.
Here you can see the interesting details of such an important collaboration. Dr Carlos Gual’s collaborations are printed on the official Nobel Lecture 1977.
https://www.incmnsz.mx/imagenes/endocrinoGUAL.pdf
I was delighted to read your article because it’s a close story to me. My late grandfather (died January 2024) is Dr Carlos Gual, close collaborator with Andrew Schally, Your article seems to overlook the importance of this collaboration and I am curious why. The first clinical studies on thyrotropin releasing hormone were carried out by Dr Gual.
The Nobel Prize is the worst thing that ever happened to science. It turns adult scientists into hysterical toddlers demanding the biggest piece of candy in the pile.
Darwin, Newton, and Aristotle didn't receive Nobel Prizes. So were they losers?
Thankfully, there is no Nobel Prize in mathematics, so mathematicians can respect each other for their genuine accomplishments, not for a stupid prize awarded by idiots.
I propose that the Nobel Prize be reformed as follows: Let it be awarded by an AI to other AIs. This way, human scientists can stop obsessing about the Prize and regain their dignity.
The two protagonists in your tale, with their millions of animal brains, sound more like Nazi concentration camp doctors than seekers after truth. I never heard of them before this and I wish them a well-deserved obscurity.
Mathematicians have an equivalent vice: the Fields Medal. In college, the math majors were the most elitist bunch I’d ever met, replete with a password-protected study room that was off-limits to non-math majors.
I was a math major in college and I went to grad school in math. I thought the mathematicians were a good bunch. It wasn't our fault that we were smarter than everyone else ;->.
I don't recall mathematicians caring much about the Fields Medal. Definitely not to the extent that some scientists are crazed about the NP.
Do you consider yourself a purist too? Never understood why mathematicians thought applying STEM to alleviate suffering was a less noble pursuit than STEM for STEM’s sake. The entire premise is dripping with ableist privilege.
I invite you to meet a mathematician of my acquaintance: Math Jesus.
https://dente.substack.com/p/hypothesis-mathematical-talent-follows?r=25gwo2